THE MENSTRUAL CYCLE SUBWAY LINE

Design and Concept by: Dr. Kyan Lynch

Content by: Dr. Mary Towner

University of Rochester Department of OBGYN

Menstruation Station

Transfer from the              to the             here

L

F

Granulosa Street Station
Hypothalamic-Pituitary-Ovarian Axis:

Increased estrogen leads to a decrease in FSH due to negative feedback

  1. Increase in the number of granulosa cells

  2. Increase in gap junctions between granulosa cells and oocyte

  3. Increase in FSH receptors on granulosa cells

  4. Increased E2 production by granulosa cells

Ovary:
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Luteal Line

(Express)

L

Follicular Line

(Local)

F

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AMH Boulevard

Ovary:
  1. Follicles release AMH, leading to proliferation of nearby folicles

Luteal Phase

The Luteal Phase, like an Express Train, follows a predictable course, avoiding unneccesary delays. 

 

Other stuff about the Luteal Phase...

Track Maintenance

If not enough "hormone" is produced at this point in the cycle, a delay of several days is common. 

 

This is the cause of abnormal uterine bleeding in patients with Disorder.  

Inhibin-B Bay

Hypothalamic-Pituitary-Ovarian Axis:

Increase in Inhibin-B leads to a decrease in FSH via negative feedback.

Ovary:

Antral follicles release Inhibin-B

Inhibin-B Bay

Hypothalamic-Pituitary-Ovarian Axis:

Increase in Inhibin-B leads to a decrease in FSH via negative feedback.

Ovary:

Antral follicles release Inhibin-B

Transit Time Variability

Like a train running a Local Service, the Follicular Phase can vary in length depending on the number of stops added to the route.

The time required to "get Hormone levels sufficiently elevated" to reach the next station can vary from person to person.  This is one of the main reasons for menstrual cycle length variability.  

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Midcycle Circle

Transfer from the              to the             here

L

F